A number of documents describe the usefulness of the pyroglutamic acid radical (also called Sodium PCA). This usefulness is most seen in the area of dermatology and cosmetics, and is specially backed-up by the fact that the sodium salt of pyroglutamic acid prevents dehydration of the skin and makes it soft, supple and elastic.

Sodium PCA is an organically expressed component of human skin and a part of the "natural moisturizing factors" (NMF) that keep skin healthy. Sodium PCA is highly hygroscopic, attracting moisture from the air. It imparts a moist feeling to hair and skin. Sodium PCA administered to the skin is assimilated to a limited extent. It is non-comedogenic, non-irritating to the eye and skin -- even at concentrations up to 50%, and does not contribute to phototoxicity or sensitization. It is quickly biodegradable. Soluble in water and ethanol and insoluble in oils, it is used for its powerful humectant properties in many health and beauty solutions including lotions, gels, shampoos, conditioners, lipsticks, creams and foundations.

One of the main elements in keeping skin healthy is making sure the structure of the epidermis (outer layer of skin) is intact. That structure is determined and composed by skin cells that are held together by the intercellular matrix. The intercellular matrix is the "glue" or "mortar" between skin cells that keep them together. It helps prevent individual skin cells from losing water and makes the smooth, non-flaky appearance of healthy, flawless skin. The components that do this are usually called biological moisturizing factors (NMFs) or ingredients that imitate the structure and function of healthy skin. While the oil and fat components of skin prevent evaporation and provide lubrication to the surface of skin, it is actually the intercellular matrix along with the skin's lipid content that confers skin a good deal of its surface texture and feel.

The intercellular matrix is the skin's first line of defense against water loss. When the lipid and NMF content of skin is reduced, we notice flaking, fine lines, surface roughness, and a tight, uncomfortable feeling. The longer the skin's surface layer (stratum corneum) is altered, the less efficient the skin's intercellular matrix becomes. Moreover, the skin's healing process is impaired. All of the skin's supporting NMFs and lipids are present in the intercellular structure of the epidermis, both between skin cells and in the lipid content on the surface of skin. When any of these ingredients are included in skin-care products, they appear to aid stabilize and keep this intricate intercellular-skin matrix. More important, all of these components, and many others, can help support the intercellular area of the skin by keeping it flawless. This support aids prevent surface irritation from penetrating deeper into the skin, works to keep microbes out, and reinforces the skin's defensive/healing system. Selecting moisturizers of any kind with NMFs (whether they are labeled as being lotions, antiwrinkle, serums, antiaging, or sunscreens) allows your skin to do its job of curing and rejuvenating itself without the difficulties brought on when skin is suffering from dryness and excess irritation.